For cases of CCB poisoning where cardiotoxicity is evident, a combination of calcium and epinephrine should be used initially, reserving HDIDK for refractory cases. For cases of beta-blocker poisoning where symptomatic bradycardia and hypotension are present, high-dose glucagon is considered the first-line antidote. Poisoning by beta-blockers or CCBs usually produces hypotension and bradycardia, which may be refractory to standard resuscitation measures. Health-system pharmacists should be aware that when these drugs are used as antidotes, higher than normal dosing is needed. ![]() For cases of CCB poisoning where cardiotoxicity is evident, first-line therapy is a combination of calcium and epinephrine high-dose insulin with supplemental dextrose and potassium therapy (HDIDK) is reserved for refractory cases. Traditionally, antidotes for CCB overdose have included calcium, glucagon, adrenergic drugs, and amrinone. However, in beta-blocker poisoning where symptomatic bradycardia and hypotension are present, high-dose glucagon is considered the first-line antidote. Therapies include beta-agonists, glucagon, and phosphodiesterase inhibitors. Poisoning by CCBs is characterized by cardiovascular toxicity with hypotension and conduction disturbances, including sinus bradycardia and varying degrees of atrioventricular block. The common feature of beta-blocker toxicity is excessive blockade of the beta-receptors resulting in bradycardia and hypotension. In overdose, beta-blockers and CCBs have similar presentation and treatment overlaps and are often refractory to standard resuscitation measures. Glucagon can also be used to manage CCB toxicity because not only is it difficult to distinguish an overdose of a -blocker from an overdose of a CCB, as the two types of medications are. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. ![]() ![]() Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed.
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The Direct Rendering Manager (DRM) / Kernel Mode-Setting (KMS) driver updates have been submitted for the Linux 6.1 merge window. The film was strongly inspired by the visual aesthetic and stylistics of Brickfilms and qualities attributed to Lego Studios sets. Chris McKay was brought in to co-direct in 2011 with Lord and Miller, and later became the film's animation supervisor. in November 2011 with a planned 2014 release date. It was officially green-lit by Warner Bros. By August 2009, it was announced that Dan and Kevin Hageman had begun writing the script. to form his own production company, Lin Pictures. ![]() Plans of a feature film based on Lego started in 2008 following a discussion between producers Dan Lin and Roy Lee, before Lin left Warner Bros. 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